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In recent years, we and others have proposed that cotinine functions as a positive allosteric modulator (PAM) of 7 nAChRs (Echeverria and Zeitlin, 3 H] DA release assays and ligand-binding autoradiography in monkeys striatum, it was discovered that cotinine functionally interacts with both 42 and 362 subtypes of nicotinic receptors in the caudate promoting DA release

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See Table 2 for mean RRs at other exposure levels